An archaeal CBASS shows protective activity against both chronic and lytic viruses
Deepak Kumar Choudhary, Himani Singla, Dana Vassover, Noam Golan, Leah Reshef, Hadar Shukrun, Aime Bienfait Igiraneza, Mechthild Pohlschröder, Uri Gophna
This study shows that the archaeal CBASS system H-CBASS2 protects against both lytic and chronic viruses by depleting NAD+, with different kinetics depending on infection type.
bioRxiv · Sep 12, 2024 · PreprintMicrobiology