A TIR-SAVED effector mediates antiviral immunity via a conserved host signal
Deepak Kumar Choudhary, Dana Vassover, Himani Singla, Hadar Shukrun, Uri Gophna
This study shows a TIR-SAVED effector can act independently as an antiviral defense, clearing viruses without its cyclase partner and using a host-produced second messenger.
bioRxiv · Jun 19, 2025 · PreprintMicrobiology