Mutant EZH2 alters the epigenetic network and increases epigenetic heterogeneity in B cell lymphoma
Ofir Griess, Noa Furth, Nofar Harpaz, Nicoletta Di Bernardo, Tomer‐Meir Salame, Bareket Dassa, Ioannis Karagiannidis, Yusuke Isshiki, Menachem Gross, Ari M. Melnick, Wendy Béguelin, Guy Ron, Efrat Shema
This study investigates how mutant EZH2 affects the epigenetic network in B cell lymphomas, showing it increases epigenetic heterogeneity and dominates over KMT2D mutations.
PLoS Biology · Jun 12, 2025Peer-reviewedCancer Biology