Tomer‐Meir Salame

This study shows that disrupting the brain-spleen axis accelerates disease progression in amyloidosis by impairing monocyte-microglia communication.

The paper identifies a subset of senescent cells marked by surface ATP6V1B2 that exhibit increased resistance to apoptosis and are associated with DNA repair.

The paper creates a spatial atlas of human gastrointestinal GVHD, identifying immune and epithelial changes that contribute to disease pathophysiology.

This study identifies impaired bone marrow myelopoiesis in Alzheimer's disease, driven by type I interferon signaling, and shows that targeting this pathway improves myeloid function and cognitive outcomes.

This study investigates how mutant EZH2 affects the epigenetic network in B cell lymphomas, showing it increases epigenetic heterogeneity and dominates over KMT2D mutations.

The paper shows that persistent ECM scarring in the colon reprograms intestinal stem cells to drive chronic inflammation through a modECM niche.

The paper identifies Arrdc4's role in suppressing pyroptosis in biphenotypic EMT cells, linking its downregulation to increased metastatic potential and poor prognosis in breast cancer.

The paper uses spatial proteomics and transcriptomics to analyze sentinel lymph nodes in melanoma patients, identifying immune patterns that predict distant metastases.

The paper identifies Mif as a regulator of tumor immune evasion in low intra-tumor heterogeneity melanoma by analyzing single-cell RNA sequencing data and validating in patient data.

The paper introduces an AID library for on-demand protein depletion in yeast, enabling systematic study of protein function and uncovering new roles in cell cycle and mitochondrial processes.

The paper identifies TGF-β signaling as a regulator of natural killer cell function in both pregnancy and tumor progression by analyzing immune compartment dynamics in human and mouse models.

This paper introduces CombPlex, a combinatorial staining method combined with deep learning to measure more proteins at single-cell resolution without needing specialized imaging equipment.

The paper introduces a method to reconstruct real-time dynamics from single-cell trajectories by estimating cell density, flux, division, and apoptosis rates, validated on mouse thymus data.

The paper identifies bi-fated tendon-to-bone attachment cells regulated by shared enhancers and KLF transcription factors, revealing how these cells integrate chondrocyte and tenocyte features.

The paper identifies a pre-symptomatic extracellular-matrix signature in colitis models and validates it in human subjects, showing its mediation by neutrophils and monocytes.

The paper identifies global and regional genetic regulators that control the modular patterning of bone superstructures during long bone development.