Author

Efrat Shema

Weizmann Institute of ScienceORCID 0000-0002-3718-593XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:chromatin & epigenetic regulation· 2 Assay:DNA methylation· 2 Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

Guy RoniD· 3 shared Bareket DassaiD· 2 shared Noa FurthiD· 2 shared Ofir GriessiD· 2 shared Albert Fradera-SolaiD· 1 shared Albrecht StenzingeriD· 1 shared Alexander Plotnikov· 1 shared Alexander Schramm· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersCancer Biology

Guy RonORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Loss of the Y chromosome drives epigenetic and transcriptomic plasticity in lung adenocarcinoma

Kathleen Schlüter, Mei-Ju May Chen, Gizem Altun, Sergio Manzano-Sanchez, Dung-Chi Wu, Nan Zhang, Ofir Griess, Luc Husemann, Fabian Bradic, Joseph Cornick, Nima Esmaeelpour, Oliver Mücke, Riccardo Moro, Katherine Kelly, Sara Chocarro, , Maria Llamazares Prada

This study shows that loss of the Y chromosome in lung adenocarcinoma causes epigenetic and transcriptomic changes that increase lineage plasticity and poor clinical outcomes.

bioRxiv · Jun 5, 2026 · PreprintCancer Biology

Mutant EZH2 alters the epigenetic network and increases epigenetic heterogeneity in B cell lymphoma

Ofir Griess, Noa Furth, Nofar Harpaz, Nicoletta Di Bernardo, Tomer‐Meir Salame, Bareket Dassa, Ioannis Karagiannidis, Yusuke Isshiki, Menachem Gross, Ari M. Melnick, Wendy Béguelin, Guy Ron, Efrat Shema

This study investigates how mutant EZH2 affects the epigenetic network in B cell lymphomas, showing it increases epigenetic heterogeneity and dominates over KMT2D mutations.

PLoS Biology · Jun 12, 2025Peer-reviewedCancer Biology

Dual Targeting of Histone Deacetylases and MYC as Potential Treatment Strategy for H3-K27M Pediatric Gliomas

Danielle Algranati, Roni Oren, Bareket Dassa, Liat Fellus-Alyagor, Alexander Plotnikov, Haim Barr, Alon Harmelin, Nir London, Guy Ron, Noa Furth, Efrat Shema

This study investigates dual targeting of HDACs and MYC in H3-K27M pediatric gliomas, showing synergistic effects in reducing cell viability and tumor growth.

bioRxiv · Feb 5, 2024Cancer Biology