Author

Ofir Griess

Weizmann Institute of ScienceORCID 0000-0002-8908-820XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:chromatin & epigenetic regulation· 2 Assay:DNA methylation· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

Efrat ShemaiD· 2 shared Guy RoniD· 2 shared Albert Fradera-SolaiD· 1 shared Albrecht StenzingeriD· 1 shared Alexander Schramm· 1 shared Ari M. MelnickiD· 1 shared Assaf ZemachiD· 1 shared Aviva KatziD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersCancer Biology

Efrat ShemaORCID

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3 papers

Recent·Most cited

Loss of the Y chromosome drives epigenetic and transcriptomic plasticity in lung adenocarcinoma

Kathleen Schlüter, Mei-Ju May Chen, Gizem Altun, Sergio Manzano-Sanchez, Dung-Chi Wu, Nan Zhang, Ofir Griess, Luc Husemann, Fabian Bradic, Joseph Cornick, Nima Esmaeelpour, Oliver Mücke, Riccardo Moro, Katherine Kelly, Sara Chocarro, , Maria Llamazares Prada

This study shows that loss of the Y chromosome in lung adenocarcinoma causes epigenetic and transcriptomic changes that increase lineage plasticity and poor clinical outcomes.

bioRxiv · Jun 5, 2026 · PreprintCancer Biology

Mutant EZH2 alters the epigenetic network and increases epigenetic heterogeneity in B cell lymphoma

Ofir Griess, Noa Furth, Nofar Harpaz, Nicoletta Di Bernardo, Tomer‐Meir Salame, Bareket Dassa, Ioannis Karagiannidis, Yusuke Isshiki, Menachem Gross, Ari M. Melnick, Wendy Béguelin, Guy Ron, Efrat Shema

This study investigates how mutant EZH2 affects the epigenetic network in B cell lymphomas, showing it increases epigenetic heterogeneity and dominates over KMT2D mutations.

PLoS Biology · Jun 12, 2025Peer-reviewedCancer Biology

Non-CG methylation is superior to CG methylation in genome regulation

Katherine Domb, Aviva Katz, Rafael Yaari, Efrat Kaisler, Vu Hoang Nguyen, Uyen Vu Thuy Hong, Ofir Griess, Karina G. Heskiau, Nir Ohad, Assaf Zemach

The paper shows non-CG methylation compensates for CG methylation loss in genome regulation, with non-CG methylation being more critical for transposon silencing.

bioRxiv · Mar 4, 2020 · PreprintGenomics