Osteoblast-derived Nerve Growth Factor is Required for Skeletal Adaptation to Mechanical Load and the Osteoanabolic Effect of Gambogic Amide in Mice
Ibtesam Rajpar, Eric McLaughlin, Gabriella Fioravanti, Nicholas J. Ruggiero, Nohael Cherian, Liliana Minichiello, Ryan E. Tomlinson
This study shows that osteoblast-derived NGF is essential for bone adaptation to mechanical load and that gambogic amide requires endogenous NGF for its osteoanabolic effects in mice.
bioRxiv · Jul 8, 2025 · PreprintBioengineering