Ibtesam Rajpar

This study shows phosphocitrate is more effective than pyrophosphate in reducing calcification in PXE mice, with better oral bioavailability and fewer side effects.

This study identifies ABCC6 and ANK as regulators of extracellular pyrophosphate and citrate, showing their roles in mineral deposition and bone health, with ANK also preventing soft tissue calcification.

This study shows that only very high oral doses of pyrophosphate inhibit ectopic calcification in Abcc6-/- mice, but these doses harm bone structure and are impractical for human use.

This study shows that osteoblast-derived NGF is essential for bone adaptation to mechanical load and that gambogic amide requires endogenous NGF for its osteoanabolic effects in mice.

This study examines the effects of celecoxib and muMab911 on bone remodeling and fracture repair in mice, finding they suppress NGF expression and load-induced bone formation, potentially contributing to rapid osteoarthritis progression.