Nicholas J. Ruggiero

Osteoblast-derived Nerve Growth Factor is Required for Skeletal Adaptation to Mechanical Load and the Osteoanabolic Effect of Gambogic Amide in Mice

This study shows that osteoblast-derived NGF is essential for bone adaptation to mechanical load and that gambogic amide requires endogenous NGF for its osteoanabolic effects in mice.

The Effect of Celecoxib and muMab911 on Strain Adaptive Bone Remodeling and Fracture Repair in Female Mice: Implications for Rapidly Progressive Osteoarthritis

This study examines the effects of celecoxib and muMab911 on bone remodeling and fracture repair in mice, finding they suppress NGF expression and load-induced bone formation, potentially contributing to rapid osteoarthritis progression.