HIV-1 subtype C LTR Sp1IIIT5A mutant enhances transcription activity and Sp1 binding affinity
Nomcebo Msthali, Ibrahim Oluwatobi Kehinde, Rene Bernadette Khan, Mahmoud E. S. Soliman, Thumbi Ndung’u, Paradise Madlala
This study shows that the Sp1IIIT5A mutation in HIV-1C LTR increases transcription activity and Sp1 binding affinity, enhancing viral replication and potentially contributing to disease progression.
bioRxiv · Jan 23, 2025 · PreprintMicrobiology