Author

Rene Bernadette Khan

University of KwaZulu-NatalORCID 0000-0002-3589-6869Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:mixed model· 2 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Approach:mechanistic / dynamical model· 1 Assay:protein structure· 1 Approach:statistical model· 1

Frequent Co-Authors

Anou Moise SomboroiD· 2 shared Daniel Gyamfi AmoakoiD· 2 shared Hezekiel Mathambo KumaloiD· 2 shared Ndumiso M. Buthelezi· 2 shared Elliasu Yakubu SalifuiD· 1 shared Ibrahim Oluwatobi KehindeiD· 1 shared Mahmoud E. S. SolimaniD· 1 shared Ndumiso Nhlakanipho MhlongoiD· 1 shared

Activity by Year

2022-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersBioinformatics

Anou Moise SomboroORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

HIV-1 subtype C LTR Sp1IIIT5A mutant enhances transcription activity and Sp1 binding affinity

Nomcebo Msthali, Ibrahim Oluwatobi Kehinde, Rene Bernadette Khan, Mahmoud E. S. Soliman, Thumbi Ndung’u, Paradise Madlala

This study shows that the Sp1IIIT5A mutation in HIV-1C LTR increases transcription activity and Sp1 binding affinity, enhancing viral replication and potentially contributing to disease progression.

bioRxiv · Jan 23, 2025 · PreprintMicrobiology

Molecular Dynamic Investigation of H5N1 Influenza Virus Dual H274Y-I222K Mutation Resistance to Peramivir

Ndumiso M. Buthelezi, Sphamandla E. Mtambo, Daniel Gyamfi Amoako, Anou Moise Somboro, Elliasu Yakubu Salifu, Rene Bernadette Khan, Ndumiso Nhlakanipho Mhlongo, Hezekiel Mathambo Kumalo

This study uses molecular dynamics to analyze how mutations in H5N1 influenza virus neuraminidase affect Peramivir binding, finding that mutations reduce binding stability and drug efficacy.

bioRxiv · Mar 8, 2022 · PreprintBioinformatics

A molecular dynamic investigation of Human Rhinovirus 3C Protease Drug Target: Insights towards the design of potential Inhibitors

Ndumiso M. Buthelezi, Daniel Gyamfi Amoako, Anou Moise Somboro, Rene Bernadette Khan, Hezekiel Mathambo Kumalo

The paper uses molecular dynamics to compare binding affinities of two HRV-3C protease inhibitors, identifying key residues involved in ligand-enzyme interactions.

bioRxiv · Mar 6, 2022 · PreprintBioinformatics