Author

Paradise Madlala

University of KwaZulu-NatalORCID 0000-0003-0641-1452Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:DNA methylation· 2 Approach:statistical model· 2 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Approach:mechanistic / dynamical model· 1

Frequent Co-Authors

Thumbi Ndung’uiD· 3 shared Krista L. DongiD· 2 shared Shreyal Maikoo· 2 shared Ibrahim Oluwatobi KehindeiD· 1 shared Kasmira GopeeiD· 1 shared Mahmoud E. S. SolimaniD· 1 shared Nomcebo Msthali· 1 shared Rene Bernadette KhaniD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersMolecular Biology

Thumbi Ndung’uORCID

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3 papers

Recent·Most cited

MicrobiologybioRxivPreprintJan 23, 2025

HIV-1 subtype C LTR Sp1IIIT5A mutant enhances transcription activity and Sp1 binding affinity

Nomcebo Msthali, Ibrahim Oluwatobi Kehinde, Rene Bernadette Khan…·Paradise Madlala

This study shows that the Sp1IIIT5A mutation in HIV-1C LTR increases transcription activity and Sp1 binding affinity, enhancing viral replication and potentially contributing to disease progression.

DOI 10.1101/2025.01.23.634640

humanDNA methylation

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Molecular BiologybioRxivPreprintAug 2, 2024

Development of a latency model based on HIV-1 subtype C to study how long terminal repeat genetic variation impacts viral persistence and latency reversal

Shreyal Maikoo, Robert-Jan T. S. Palstra, Krista L. Dong…·Paradise Madlala

DOI 10.1101/2024.08.02.606371

humanexperimental assay

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Molecular BiologyPLoS PathogensPeer-reviewedJun 12, 2023

Genetic variation of the HIV-1 subtype C transmitted/founder viruses long terminal repeat elements and the impact on transcription activation potential and clinical disease outcomes

Paradise Madlala, Zakithi Mkhize, Shamara Naicker…·Thumbi Ndung’u

This study examines HIV-1 subtype C transmitted/founder virus LTR genetic variation and its impact on transcriptional activity and clinical outcomes.

13 citations

humanDNA methylation

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