Premature aging in aneuploid yeast is caused in part by aneuploidy-induced defects in Ribosome Quality Control
Leah E. Escalante, James Hose, Hollis Howe, Norah Paulsen, Michael Place, Audrey P. Gasch
This study shows that aneuploidy in yeast causes premature aging by disrupting ribosome quality control, leading to protein aggregates and cyclin dysregulation.
bioRxiv · Jun 22, 2024 · PreprintMolecular Biology