Michael Place

This paper identifies SigAb as a metal stress-responsive ECF σ factor in Acinetobacter baumannii, showing it directly regulates a small set of genes and indirectly controls hundreds involved in metal resistance and fitness.

This study identifies how altering translation in E. coli mitigates the growth inhibition caused by chemically stabilized G-quadruplexes.

The paper quantifies the fitness cost of aneuploidy in yeast by analyzing chromosome duplications and identifies gene length as a key determinant of toxicity.

This study shows that aneuploidy in yeast causes premature aging by disrupting ribosome quality control, leading to protein aggregates and cyclin dysregulation.

The paper develops CRISPRtOE, a genome-scale overexpression platform for Proteobacteria, demonstrating its use in Escherichia coli and Zymomonas mobilis to identify antibiotic and engineering targets.

This study identifies genetic interactions linking the PriA/PriB DNA replication restart pathway to double-strand DNA break repair in E. coli using transposon insertion sequencing and targeted experiments.

The paper measures fitness costs of overexpressed genes in yeast strains to show natural variation in tolerance to gene overexpression and its evolutionary implications.

CRISpy-pop designs and predicts CRISPR/Cas9 guide RNA activity across diverse yeast and bacterial strains, including human genome cross-referencing for biosafety.

The paper infers a signaling network regulating phosphorylation changes in yeast during salt stress, revealing novel interactions between stress and growth pathways.

The paper uses genome-wide association analysis in yeast strains to identify genetic factors affecting toxin tolerance, finding significant strain-specific variation in gene importance.

The paper uses single-cell RNA-seq to study stress response heterogeneity in yeast, finding regulatory variation and decoupled transcription-factor activation.