James Hose

The response to single-gene duplication implicates translation as a key vulnerability in aneuploid yeast

The paper investigates the response to single-gene duplication in yeast, finding that translation-related genes are particularly deleterious in aneuploid cells lacking the RNA-binding protein Ssd1.

On the rate of aneuploidy reversion in a wild yeast model

This paper measures aneuploidy reversion rates in yeast using a fluctuation assay, showing fitness effects influence estimates and chromosome-specific loss rates.

Comparative modeling reveals the molecular determinants of aneuploidy fitness cost in a wild yeast model

The paper quantifies the fitness cost of aneuploidy in yeast by analyzing chromosome duplications and identifies gene length as a key determinant of toxicity.

Premature aging in aneuploid yeast is caused in part by aneuploidy-induced defects in Ribosome Quality Control

This study shows that aneuploidy in yeast causes premature aging by disrupting ribosome quality control, leading to protein aggregates and cyclin dysregulation.

Modeling single-cell phenotypes links yeast stress acclimation to transcriptional repression and pre-stress cellular states

The paper models single-cell phenotypes in yeast to show that transcriptional repression during stress improves post-stress growth recovery.

Natural variation in the consequences of gene overexpression and its implications for evolutionary trajectories

The paper measures fitness costs of overexpressed genes in yeast strains to show natural variation in tolerance to gene overexpression and its evolutionary implications.

Genetic variation in aneuploidy prevalence and tolerance across the Saccharomyces cerevisiae phylogeny

The paper investigates how genetic background influences aneuploidy prevalence and tolerance in Saccharomyces cerevisiae across different clades.

Genome-wide association across Saccharomyces cerevisiae strains reveals substantial variation in underlying gene requirements for toxin tolerance.

The paper uses genome-wide association analysis in yeast strains to identify genetic factors affecting toxin tolerance, finding significant strain-specific variation in gene importance.

Single-cell RNA-seq reveals intrinsic and extrinsic regulatory heterogeneity in yeast responding to stress

The paper uses single-cell RNA-seq to study stress response heterogeneity in yeast, finding regulatory variation and decoupled transcription-factor activation.