Author

Leah E. Escalante

University of Wisconsin–MadisonORCID 0009-0004-6730-2297Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Approach:statistical model· 2 Organism:yeast· 2 Research Focus:cell type annotation· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Audrey P. GaschiD· 2 shared James Hose· 2 shared Michael PlaceiD· 2 shared Christina M. KendziorskiiD· 1 shared Doina CiobanuiD· 1 shared Feiqiao Brian YuiD· 1 shared Hollis Howe· 1 shared Igor V. GrigorieviD· 1 shared

Activity by Year

2017-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersMolecular Biology

Audrey P. GaschORCID

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2 papers

Recent·Most cited

Premature aging in aneuploid yeast is caused in part by aneuploidy-induced defects in Ribosome Quality Control

Leah E. Escalante, James Hose, Hollis Howe, Norah Paulsen, Michael Place, Audrey P. Gasch

This study shows that aneuploidy in yeast causes premature aging by disrupting ribosome quality control, leading to protein aggregates and cyclin dysregulation.

bioRxiv · Jun 22, 2024 · PreprintMolecular Biology

Single-cell RNA-seq reveals intrinsic and extrinsic regulatory heterogeneity in yeast responding to stress

Audrey P. Gasch, Feiqiao Brian Yu, James Hose, Leah E. Escalante, Michael Place, Rhonda L. Bacher, Jad N. Kanbar, Doina Ciobanu, Laura Sandor, Igor V. Grigoriev, Christina M. Kendziorski, Stephen R. Quake, Megan N. McClean

The paper uses single-cell RNA-seq to study stress response heterogeneity in yeast, finding regulatory variation and decoupled transcription-factor activation.

PLoS Biology · Dec 14, 2017Peer-reviewedSystems Biology