ER-Lysosome Cholesterol Exchange Regulates Lysosomal Motility Through mTOR-Dependent LAMTOR1 Phosphorylation
Pathma Muthukottiappan, Alireza Dehghani, Asisa Muchamedin, Michael Ebner, Mariana E. G. de Araújo, Cristina Coman, Sönke Rudnik, Milash Balachandran, Sofía Fajardo‐Callejón, Fatema Akter, Norbert Rösel, Paul Säftig, Markus Daμμe, Robert Ahrends, Lukas Alfons Huber, , Dominic Winter
The paper identifies that lysosomal cholesterol exchange regulates motility through mTOR-dependent LAMTOR1 phosphorylation, revealing a feedback mechanism affecting mTORC1 activity and lysosomal movement.
bioRxiv · Mar 31, 2026 · PreprintMolecular Biology