Paul Säftig

This study shows TMEM55B and TMEM55A regulate lysosome distribution in neurons by affecting motor protein transport, with TMEM55B specifically promoting anterograde transport of LAMP1-positive organelles.

The paper identifies that lysosomal cholesterol exchange regulates motility through mTOR-dependent LAMTOR1 phosphorylation, revealing a feedback mechanism affecting mTORC1 activity and lysosomal movement.

This study shows that ADAM10's non-catalytic function, not its enzymatic activity, regulates hepatic progenitor cell fate and liver regeneration.

The paper identifies MFSD1 as a lysosomal dipeptide uniporter that facilitates the transport of cationic and neutral dipeptides when amino acid exporters are overloaded.

This study shows that Tspan15 depletion in mice increases social investigation and aggression, suggesting a role in neuronal circuits controlling aggressive behavior.

This study identifies ADAM10's localization to presynaptic vesicles and shows its role in synaptic facilitation through interaction with synaptotagmin 7, independent of its proteolytic activity.

The paper shows that ligands binding to PrPC induce its proteolytic release, which has neuroprotective effects, and identifies mechanisms and exceptions in this process.