Population Performance and Individual Agreement of Coronary Artery Disease Polygenic Risk Scores
Sarah A. Abramowitz, Kristin M. Boulier, Karl Keat, Katie M. Cardone, Manu Shivakumar, John S. DePaolo, Renae Judy, Francisca Bermudez, Nour Mimouni, Christopher J. Neylan, Dokyoon Kim, Daniel James Rader, Marylyn DeRiggi Ritchie, Benjamin F. Voight, Bogdan Paşaniuc, , Theodore G. Drivas
This study evaluates the reliability of coronary artery disease polygenic risk scores across diverse populations, finding poor individual agreement despite equivalent population-level performance.
JAMA · Nov 16, 2024Peer-reviewedGenetic & Genomic Medicine