Wenqin Luo

This paper develops Scratch-AID+, an automated mouse scratching detection framework, showing that fine-tuned video foundation models outperform classic models in generalizability and accuracy.

This study shows that sensory neuron subsets differentially modulate psoriasiform inflammation by shaping γδ T cell effector programs.

The paper shows that TRPV1+ afferents rapidly reprogram TRPV1- Aβ afferents, leading to hyperalgesia in humans.

This paper constructs a human dorsal root ganglion reference atlas, identifying 22 neuronal subtypes and 10 non-neuronal cell types, and reveals functional differences between human and mouse DRG neurons.

The paper evaluates segmentation methods in spatial transcriptomics, showing that manual review is necessary due to model-specific errors.

This study shows that TRPV1+ neurons promote cutaneous immunity against Schistosoma mansoni by regulating immune cell responses and limiting parasite dissemination.

This paper identifies cell-type-specific genetic variants associated with chronic pain using GWAS and scRNA-seq data from brain and dorsal root ganglia tissues.

This study develops a method to sequence individual human DRG neuron somas, identifies 16 neuronal types, and reveals human-specific nociceptor types and potential drug targets.

The paper identifies PIEZO2-dependent mechanical pain in humans and mice, showing hair-pull pain is mediated by Aβ inputs and specific nociceptors.

This study investigates the distinct roles of Aβ low-threshold mechanoreceptors in mechanical pain transmission, finding they have both local and global functions in hyperalgesia.

Scratch-AID automatically detects and quantifies mouse scratching behavior with high accuracy, outperforming manual methods in various itch models and drug screening applications.

This study shows that aversive learning increases the release probability of olfactory sensory neurons in mice, correlating with freezing behavior during fear retrieval.

The paper identifies MRGPRX4 as a novel bile acid receptor involved in cholestatic itch, showing its activation by bile acids and its role in itch induction in humans.

The paper shows that region-specific central arbor morphologies of Mrgprd+ nociceptors develop independently of peripheral target innervation.

This study uses high-speed videography and machine learning to objectively assess mouse pain state through paw withdrawal reflex parameters.

The paper uses genetic tracing in mice to show that nociceptors in different body regions have distinct central arbor structures, which may explain the high spatial acuity for pain in the limbs.