Huasheng Yu

This paper develops Scratch-AID+, an automated mouse scratching detection framework, showing that fine-tuned video foundation models outperform classic models in generalizability and accuracy.

This study shows that sensory neuron subsets differentially modulate psoriasiform inflammation by shaping γδ T cell effector programs.

The paper shows that TRPV1+ afferents rapidly reprogram TRPV1- Aβ afferents, leading to hyperalgesia in humans.

This paper constructs a human dorsal root ganglion reference atlas, identifying 22 neuronal subtypes and 10 non-neuronal cell types, and reveals functional differences between human and mouse DRG neurons.

The paper evaluates segmentation methods in spatial transcriptomics, showing that manual review is necessary due to model-specific errors.

This paper identifies cell-type-specific genetic variants associated with chronic pain using GWAS and scRNA-seq data from brain and dorsal root ganglia tissues.

This study develops a method to sequence individual human DRG neuron somas, identifies 16 neuronal types, and reveals human-specific nociceptor types and potential drug targets.

The paper identifies PIEZO2-dependent mechanical pain in humans and mice, showing hair-pull pain is mediated by Aβ inputs and specific nociceptors.

This study investigates the distinct roles of Aβ low-threshold mechanoreceptors in mechanical pain transmission, finding they have both local and global functions in hyperalgesia.

Scratch-AID automatically detects and quantifies mouse scratching behavior with high accuracy, outperforming manual methods in various itch models and drug screening applications.

The paper identifies SLC35D3 as a vesicular transporter for UDP-glucose through localization, proteomics, and metabolite profiling in neurons.

The paper identifies MRGPRX4 as a novel bile acid receptor involved in cholestatic itch, showing its activation by bile acids and its role in itch induction in humans.