Not All Charges Are Equal: Side-Chain Chemistry Reshapes the Disordered Ensemble of α-synuclein
Gil Koren, Nuno Fernandes, Asaf Sivan, Rawan Aodeh, Dean Yona, Mathar Kravikass, Yuval Keidar, Kresten Lindorff‐Larsen, Roy Beck
This paper shows that arginine substitutions, despite similar charge, compact α-synuclein more than lysine, accelerating amyloid formation and reshaping its disordered ensemble.
bioRxiv · Jun 10, 2026 · PreprintBiophysics