Spatial transcriptomics maps region and isoform specific brain alterations in mdx and mdx4cv models of Duchenne muscular dystrophy
Qiao Mao, Laura G.M. Heezen, Sharon I. de Vries, Nynke Verwoerd, Annemieke M Aartsma-Rus, Maaike van Putten, Pietro Spitali, Ahmed Essam Mahfouz
This study uses spatial transcriptomics to compare gene expression changes in brain regions of mdx and mdx4cv DMD mouse models, revealing distinct patterns linked to dystrophin isoform loss.
bioRxiv · Oct 19, 2026 · PreprintNeuroscience