Author

Pietro Spitali

Leiden University Medical CenterORCID 0000-0003-2783-688XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Assay:spatial transcriptomics· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 1 Research Focus:spatial domain detection· 1

Frequent Co-Authors

Ahmed Essam MahfouziD· 3 shared Annemieke M Aartsma-RusiD· 3 shared Laura G.M. HeezeniD· 3 shared Maaike van PutteniD· 3 shared Qirong MaoiD· 2 shared Sharon I. de Vries· 2 shared Alireza Ahmadi· 1 shared Aurélie GoyenvalleiD· 1 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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3 shared papersNeuroscience

Ahmed Essam MahfouzORCID

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3 papers

Recent·Most cited

NeurosciencebioRxivPreprintOct 19, 2026

Spatial transcriptomics maps region and isoform specific brain alterations in mdx and mdx4cv models of Duchenne muscular dystrophy

Qiao Mao, Laura G.M. Heezen, Sharon I. de Vries…·Ahmed Essam Mahfouz

This study uses spatial transcriptomics to compare gene expression changes in brain regions of mdx and mdx4cv DMD mouse models, revealing distinct patterns linked to dystrophin isoform loss.

DOI 10.64898/2026.10.13.758478

mousespatial transcriptomics

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NeuroscienceiSciencePeer-reviewedJul 23, 2026

Evaluating exon-skipping therapies targeting the central nervous system in Duchenne muscular dystrophy using high-resolution spatial transcriptomics

Qirong Mao, Alireza Ahmadi, Sharon I. de Vries…·Pietro Spitali

This study uses spatial transcriptomics to evaluate exon-skipping therapies for DMD in the CNS, showing U7ex51 effectively restores full-length dystrophin isoforms in neurons.

DOI 10.1016/j.isci.2026.116906

mousespatial transcriptomics

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GenomicsNature CommunicationsPeer-reviewedAug 15, 2023

Spatial transcriptomics reveal markers of histopathological changes in Duchenne muscular dystrophy mouse models

Laura G.M. Heezen, Tamim Abdelaal, Maaike van Putten…·Pietro Spitali

The paper uses spatial transcriptomics in DMD mouse models to identify gene expression signatures linked to histopathological changes in skeletal muscle.

56 citationstop 3%

mousespatial transcriptomics

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