Laura G.M. Heezen

Spatial transcriptomics maps region and isoform specific brain alterations in mdx and mdx4cv models of Duchenne muscular dystrophy

This study uses spatial transcriptomics to compare gene expression changes in brain regions of mdx and mdx4cv DMD mouse models, revealing distinct patterns linked to dystrophin isoform loss.

Evaluating exon-skipping therapies targeting the central nervous system in Duchenne muscular dystrophy using high-resolution spatial transcriptomics

This study uses spatial transcriptomics to evaluate exon-skipping therapies for DMD in the CNS, showing U7ex51 effectively restores full-length dystrophin isoforms in neurons.

Spatial transcriptomics reveal markers of histopathological changes in Duchenne muscular dystrophy mouse models

The paper uses spatial transcriptomics in DMD mouse models to identify gene expression signatures linked to histopathological changes in skeletal muscle.