Replicative Instability Drives Cancer Progression
B. B. Morris, J. P. Smith, Q. Zhang, Z. Jiang, O. A. Hampton, M. L. Churchman, S. M. Arnold, D. H. Owen, J. E. Gray, P. M. Dillon, H. H. Soliman, D. G. Stover, H. Colman, A. Chakravarti, K. H. Shain, , M. W. Mayo
This study identifies a pan-cancer class of tumors driven by replicative instability, showing it accelerates cancer progression through genomic changes and transcriptional rewiring.
bioRxiv · May 6, 2022Cancer Biology