Author

S. M. Arnold

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:Drosophila· 1 Approach:genetic perturbation / CRISPR· 1 Approach:statistical model· 1

Frequent Co-Authors

H. Colman· 2 shared A. C. Boese· 1 shared A. Chakravarti· 1 shared A. I. Marcus· 1 shared A. R. Post· 1 shared A. S. Silva· 1 shared B. B. Morris· 1 shared C. Arciero· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCancer Biology

H. Colman

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Author profile →

2 papers

Recent·Most cited

Loss of the endocytic tumor suppressor HD-PTP phenocopies LKB1 and promotes RAS-driven oncogenesis.

C.-S. Seong, C. Huang, A. C. Boese, Y. Hou, J. Koo, J. K. Mouw, M. Rupji, G. Joseph, H. R. Johnston, H. Claussen, J. M. Switchenko, M. Behera, M. Churchman, J. M. Kolesar, S. M. Arnold, , M. Gilbert-Ross

The paper shows that loss of HD-PTP, a tumor suppressor, promotes RAS-driven oncogenesis and is associated with adenosquamous lung cancer, suggesting it as a therapeutic target.

bioRxiv · Jan 26, 2023 · PreprintCancer Biology

Replicative Instability Drives Cancer Progression

B. B. Morris, J. P. Smith, Q. Zhang, Z. Jiang, O. A. Hampton, M. L. Churchman, S. M. Arnold, D. H. Owen, J. E. Gray, P. M. Dillon, H. H. Soliman, D. G. Stover, H. Colman, A. Chakravarti, K. H. Shain, , M. W. Mayo

This study identifies a pan-cancer class of tumors driven by replicative instability, showing it accelerates cancer progression through genomic changes and transcriptional rewiring.

bioRxiv · May 6, 2022Cancer Biology