Z. Jiang

IDH1 regulates human erythropoiesis by eliciting chromatin state reprogramming

This study shows that IDH1 deficiency causes chromatin state reprogramming in human erythropoiesis by altering H3K79me3 distribution and upregulating SIRT1, leading to impaired erythropoiesis.

Discovery of Potent Degraders of the Dengue Virus Envelope Protein

This study develops small molecule degraders of the dengue virus envelope protein, demonstrating their ability to induce proteosome-mediated degradation and providing a foundation for antiviral drug development.

An emerging PB2-627 polymorphism increases the pandemic potential of avian influenza virus by breaking through ANP32 host restriction in mammalian and avian hosts

This paper identifies a PB2-627V mutation in avian influenza viruses that enhances pandemic potential by overcoming host restriction through ANP32A proteins in both avian and mammalian hosts.

Deciphering Arabidopsis thaliana Acclimation to Sublethal Combined Abiotic Stresses

This study investigates Arabidopsis thaliana's response to combined abiotic stresses, identifying molecular mechanisms and genes involved in stress resilience.

Deciphering the Preeclampsia-Specific Immune Microenvironment: The Role of Pro-inflammatory Macrophages

This study identifies pro-inflammatory macrophages as key regulators of the PE-specific immune microenvironment, linking them to Th17 and CD8+ T cell activation and gMDSC suppression in placental tissues.

Parallel evolution of plant alkaloid biosynthesis from bacterial-like decarboxylases

This study identifies OLADOs, a new class of eukaryotic decarboxylases involved in alkaloid biosynthesis, showing their parallel evolution from bacterial-like enzymes.

Unravelling an Efficient O2/Reductant-Dependent Catalytic Route in Heme Peroxygenases for Sustainable Applications

This paper identifies an O2/reductant-dependent catalytic pathway in heme peroxygenases that avoids H2O2-induced inactivation, enabling efficient and sustainable chemical transformations.

Discovery and binding site identification of a single-stranded DNA-binding protein that interacts with double-stranded DNA

This study identifies a single-stranded DNA-binding protein from E. coli F plasmid that also binds double-stranded DNA, revealing a previously unknown dsDNA-binding capability.

Deep mutational scanning of a multi-domain signaling protein reveals mechanisms of regulation and pathogenicity

The paper uses deep mutational scanning to analyze SHP2 mutations, revealing diverse regulatory mechanisms and potential pathogenicity of uncharacterized variants.

Beyond enumeration: Phenotype independent "labeling-capture-release" process enabling precise detection of circulating tumour cells and downstream applications

This paper introduces a labeling-capture-release method for isolating circulating tumor cells from blood samples with high efficiency and accuracy, enabling downstream applications.

Novel Ser74 of NF-kappaB/CgIkappaBalpha Phosphorylated by MAPK/ERK Regulates Temperature Adaptation in Oysters

The paper identifies a novel phosphorylation site (Ser74) in oyster NF-kappaB/CgI{kappa}B regulated by MAPK/ERK that mediates thermal adaptation through ubiquitin-proteasome degradation and nuclear translocation of CgREL.

Development of subunit selective proteasome substrates for Schistosoma species

The paper develops subunit-specific proteasome substrates for Schistosoma species, showing improved performance and cross-species applicability.

HCCDB v2.0: Decompose the Expression Variations by Single-cell RNA-seq and Spatial Transcriptomics in HCC

HCCDB v2.0 integrates bulk, single-cell, and spatial transcriptomic data from HCC samples to enhance meta-analysis and provide new metrics for gene expression patterns.

Architecture of intact mammalian pyruvate dehydrogenase complex revealed by in-situ structural analysis

This study reveals the in-situ architecture of the mammalian pyruvate dehydrogenase complex using cryo-electron tomography, showing dynamic interactions and variable peripheral compositions.

The transcription factor OsbZIP48 governs rice responses to zinc deficiency

This study identifies OsbZIP48 as a transcription factor critical for rice's response to zinc deficiency, showing it regulates zinc transporter genes through direct promoter binding.

Bacterial exonuclease III expands its enzymatic activities on single-stranded DNA

This study shows bacterial ExoIII can cleave single-stranded DNA (ssDNA) via exonuclease and endonuclease activities, revealing new enzymatic functions and implications for biosensor design.

Application of slow-controlled release fertilizer coordinates the carbon flow in carbon-nitrogen metabolism to effect rice quality

This study evaluates five slow-controlled release fertilizers on rice quality over two years, finding that BBF improves yield and grain quality by optimizing carbon-nitrogen metabolism.

A dipteran parasite regulates 20E synthesis and antibacterial activity of the host for development through inducing host nitric oxide production

This study shows that a dipteran parasite increases host nitric oxide production to regulate 20E synthesis and antibacterial activity, supporting its development.

OpenNucleome for high resolution nuclear structural and dynamical modeling

OpenNucleome enables GPU-accelerated molecular dynamics simulations of the human nucleus to model structural organization and dynamic processes, revealing mechanisms of genomic anchoring and nuclear zoning.

An atypical endomembrane localized CNL-type immune receptor with a conserved deletion in the N-terminal signaling domain functions in cell death and immunity

This study identifies an atypical plant immune receptor, PML5, with a conserved deletion in its signaling domain that mediates cell death and immunity.

PRO-LDM: Protein Sequence Generation with a Conditional Latent Diffusion Model

PRO-LDM generates protein sequences with tailored properties using a conditional latent diffusion model, enhancing diversity and design fidelity.

The pathogenic T42A mutation in SHP2 rewires the interaction specificity of its N-terminal regulatory domain

This paper investigates the T42A mutation in SHP2, showing it alters ligand-binding specificity in the N-terminal SH2 domain, leading to biased activation and enhanced signaling.

The canonical single-stranded DNA binding protein SSB is not an essential replication protein but an RNA chaperon in the hyperthermophilic archaeon Saccharolobus islandicus REY15A

This study shows that the canonical SSB in Saccharolobus islandicus REY15A is not essential for DNA replication but functions as an RNA chaperone, with conserved activities in related archaea.

Hypoxia induced oxidative stress and endoplasmic reticulum stress promoted myocardial cell fibrosis

This study shows hypoxia induces myocardial fibrosis through oxidative and endoplasmic reticulum stress, and antioxidant drugs can alleviate this effect.

Lipid-anchored Proteasomes Control Membrane Protein Homeostasis

This study identifies N-myristoylation of Rpt2 as a mechanism for proteasome-membrane interaction, showing its role in membrane protein homeostasis and its impact on cellular processes and tumor growth.

The ortholog of human REEP1-4 is required for autophagosomal enclosure of ER-phagy/nucleophagy cargos in fission yeast

This study identifies Yep1 in fission yeast as essential for autophagosomal enclosure of ER-phagy and nucleophagy cargos, revealing its role in membrane shaping and cargo separation.

Development of subunit selective substrates for Trichomonas vaginalis proteasome

The paper develops three subunit-specific fluorogenic substrates for the T. vaginalis proteasome and identifies effective inhibitor targets.

Phage administration with repeated intravenous doses leads to faster phage clearance in mammalian hosts

This study evaluates phage clearance and host responses to repeated intravenous phage doses in rats and monkeys, finding faster clearance and immune activation with repeated administration.

CD4+ T cells display a spectrum of recall dynamics during re-infection with malaria parasites.

This study examines CD4+ T cell recall dynamics during Plasmodium re-infection in mice, revealing a spectrum of responses including refractory GC Tfh cells, rapid Th1-memory responses, and a partial facsimile of primary Th1 responses.

Immature myeloid cells are indispensable for intestinal regeneration post irradiation injury

This study shows that immature myeloid cells (IMCs) are essential for intestinal regeneration after irradiation injury, driven by microbial signals and promoting epithelial repair through PGE2 production.