O. Agbulut

Critical contribution of mitochondria in the development of cardiomyopathy linked to desmin mutation

This study shows that mitochondrial defects in desmin-mutated cardiomyocytes contribute to cardiomyopathy and can be reversed by transferring normal mitochondria.

Anisotropic dense collagen hydrogels possessing two ranges of porosity to create the adequate microenvironment for muscle bundles: a step towards skeletal muscle modeling

This paper develops anisotropic dense collagen hydrogels with two porosity ranges to support myoblast differentiation into myotubes and mimic skeletal muscle ECM properties.

Receptor-interacting protein kinase-3 mediates both myopathy and cardiomyopathy in preclinical animal models of Duchenne muscular dystrophy

This study shows that inhibiting necroptosis in dystrophic mice improves cardiac and skeletal muscle function, suggesting necroptosis contributes to DMD-related myopathy and cardiomyopathy.

The beneficial effect of chronic muscular exercise on muscle fragility is increased by Prox1 gene transfer in dystrophic mdx muscle

This study shows that Prox1 gene transfer reduces muscle fragility in exercised dystrophic mdx mice but not sedentary ones, suggesting a synergistic effect with chronic exercise.

Desmin is a modifier of dystrophic muscle features in Mdx mice

This study shows that desmin deletion in Mdx mice worsens muscle weakness, fragility, and fatigue resistance, while desmin gene transfer improves these features.