Multiple Targets, One Goal: Compounding life-extending effects through Polypharmacology
Konstantin Avchaciov, Khalyd J. Clay, Kirill A. Denisov, O. Burmistrova, Michael Petrascheck, Peter O. Fedichev
The paper uses graph neural networks to predict polypharmacological compounds that extend lifespan in C. elegans, finding 70% of selected compounds significantly increase lifespan.
Aging Cell · Apr 22, 2025Peer-reviewedPharmacology & Toxicology