Michael Petrascheck

Atypical tetracyclines promote longevity and ferroptotic neuroprotection via translation attenuation

This paper identifies atypical tetracyclines that promote longevity and neuroprotection by inhibiting cytosolic translation, independent of classical mechanisms and antibiotic activity.

PIEZO channels link mechanical forces to uterine contractions in parturition

Deleting Piezo1 and Piezo2 together in mice weakens uterine contractions and prolongs labor; uterine and sensory-neuron deletions act additively, and knockout uteri show reduced Gja1 (connexin43).

Nucleosome stability safeguards cell identity, stress resilience and healthy aging

The paper shows that reduced nucleosome stability impairs cell identity, stress resilience, and healthy aging across species.

Multiple Targets, One Goal: Compounding life-extending effects through Polypharmacology

The paper uses graph neural networks to predict polypharmacological compounds that extend lifespan in C. elegans, finding 70% of selected compounds significantly increase lifespan.

Activity-dependent synthesis of Emerin gates neuronal plasticity by regulating proteostasis

The paper identifies Emerin as an activity-induced protein that gates neuronal plasticity by inhibiting protein synthesis and altering dendritic spine morphology.

Uncoupling overeating and fat storage by modulation of different serotonergic receptors

The paper shows that serotonin and antipsychotics induce hyperphagia through distinct serotonergic receptor mechanisms, uncoupling overeating from fat storage.

Predicting Mouse Lifespan-Extending Chemical Compounds with Machine Learning

This study uses machine learning to predict lifespan-extending compounds in mice by analyzing drug-target annotations, identifying key receptors and pathways associated with longevity.

The landscape of longevity across phylogeny

The paper analyzes longevity interventions across species and identifies a structured 'landscape of longevity' with soft bounds on achievable lifespan, including a human upper limit of ~138 years.

TargetSeeker-MS: A computational method for drug target discovery using protein separation coupled to mass spectrometry

TargetSeeker-MS identifies drug targets on a proteome scale using EBPS-MS data, showing reproducibility in C. elegans and HEK293 samples treated with benomyl.