Kirill A. Denisov

The paper uses graph neural networks to predict polypharmacological compounds that extend lifespan in C. elegans, finding 70% of selected compounds significantly increase lifespan.

The paper identifies thermodynamic control variables that regulate healthspan and maximum lifespan using DNA methylation data from mammals.

The paper analyzes DNA methylation and electronic health records to show aging is driven by entropy and configuration changes, with implications for age reversal.