Novel assays monitoring direct glucocorticoid receptor protein activity exhibit high predictive power for ligand activity on endogenous gene targets
L. Van Moortel, J. Thommis, B. Maertens, A. Staes, D. Clarisse, D. De Sutter, C. Libert, O. C. Meijer, S. Eyckerman, K. Gevaert, K. De Bosscher
The paper introduces novel luciferase-based assays to monitor GR protein activity and shows that GR Ser211 phosphorylation is a reliable predictor of ligand effects on endogenous gene targets.
bioRxiv · Mar 29, 2022Pharmacology & Toxicology