Author

K. De Bosscher

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 1 Cancer Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Organism:human· 2 Research Focus:benchmarking· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

D. Clarisse· 2 shared D. De Sutter· 2 shared D. Fijalkowska· 2 shared J. Thommis· 2 shared L. Van Moortel· 2 shared S. Eyckerman· 2 shared A. Staes· 1 shared A. Verhee· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCancer Biology

D. Clarisse

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Leveraging a self-cleaving peptide for tailored control in proximity labeling proteomics

L. Delhaye, G. D. Moschonas, D. Fijalkowska, A. Verhee, D. De Sutter, T. Van de Steene, M. De Meyer, L. Van Moortel, K. De Bosscher, S. Eyckerman

The paper introduces a T2A split-link system for proximity labeling proteomics to improve control over enzymatic activity and expression levels, enhancing accuracy in identifying protein interactions.

bioRxiv · Nov 3, 2023Biochemistry

Crosstalk between the glucocorticoid and mineralocorticoid receptor boosts glucocorticoid-induced killing of multiple myeloma cells

D. Clarisse, S. Prekovic, P. Vlummens, E. Staessens, K. Van Wesemael, J. Thommis, D. Fijalkowska, G. Acke, W. Zwart, I. M. Beck, F. Offner, K. De Bosscher

This study shows that combining dexamethasone with spironolactone enhances myeloma cell killing through GR-MR crosstalk, with potential for dose reduction.

bioRxiv · May 10, 2023Cancer Biology

Novel assays monitoring direct glucocorticoid receptor protein activity exhibit high predictive power for ligand activity on endogenous gene targets

L. Van Moortel, J. Thommis, B. Maertens, A. Staes, D. Clarisse, D. De Sutter, C. Libert, O. C. Meijer, S. Eyckerman, K. Gevaert, K. De Bosscher

The paper introduces novel luciferase-based assays to monitor GR protein activity and shows that GR Ser211 phosphorylation is a reliable predictor of ligand effects on endogenous gene targets.

bioRxiv · Mar 29, 2022Pharmacology & Toxicology