Bacteriophage uptake by Eukaryotic cell layers represents a major sink for phages during therapy
M. C. Bichet, W. H. Chin, W. Richards, Y.-W. Lin, L. Avellaneda-Franco, C. A. Hernandez, A. Oddo, O. Chernyavskiy, V. Hilsenstein, A. Neild, J. C. Li, N. H. Voelcker, R. Patwa, J. J. Barr
The paper shows that eukaryotic cells internalize phages, with smaller phages being taken up more efficiently, and demonstrates this impacts phage distribution and therapy efficacy.
bioRxiv · Sep 7, 2020Microbiology