Author

R. Patwa

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Research Focus:host-pathogen & immune response· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

J. J. Barr· 4 shared A. Neild· 2 shared L. Avellaneda-Franco· 2 shared M. C. Bichet· 2 shared W. H. Chin· 2 shared A. Oddo· 1 shared A. Y. Peleg· 1 shared C. A. Hernandez· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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4 shared papersMicrobiology

J. J. Barr

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Author profile →

4 papers

Recent·Most cited

Mammalian cells internalize bacteriophages and utilize them as a food source to enhance cellular growth and survival

M. C. Bichet, J. Adderley, L. Avellaneda-Franco, L. J. Gearing, C. Deffrasnes, C. David, G. Pepin, M. P. Gantier, R. C. Lin, R. Patwa, G. W. Moseley, C. Doerig, J. J. Barr

This study shows mammalian cells internalize bacteriophage T4, which enhances cellular growth and survival through AKT-dependent pathways and G1 phase prolongation without triggering inflammatory responses.

bioRxiv · Mar 10, 2023 · PreprintMicrobiology

Bacteriophage adaptation to a mammalian mucosa reveals a trans-domain evolutionary axis

W. H. Chin, C. Kett, O. Cooper, D. Müseler, Y. Zhang, R. S. Bamert, R. Patwa, L. C. Woods, C. Devendran, J. Tiralongo, T. Lithgow, M. J. McDonald, A. Neild, J. J. Barr

This study shows that bacteriophages adapt to the mammalian gut mucosa through mutations and recombination, gaining a fitness advantage by altering their binding to mucin glycans.

bioRxiv · May 11, 2021 · PreprintMicrobiology

Bacteriophage uptake by Eukaryotic cell layers represents a major sink for phages during therapy

M. C. Bichet, W. H. Chin, W. Richards, Y.-W. Lin, L. Avellaneda-Franco, C. A. Hernandez, A. Oddo, O. Chernyavskiy, V. Hilsenstein, A. Neild, J. C. Li, N. H. Voelcker, R. Patwa, J. J. Barr

The paper shows that eukaryotic cells internalize phages, with smaller phages being taken up more efficiently, and demonstrates this impacts phage distribution and therapy efficacy.

bioRxiv · Sep 7, 2020Microbiology

Bacteriophages targeting Acinetobacter baumannii capsule induce antimicrobial resensitization

F. L. Gordillo Altamirano, J. H. Forsyth, R. Patwa, X. Kostoulias, M. Trim, D. Subedi, S. Archer, F. C. Morris, C. Oliveira, L. Kielty, D. Korneev, M. K. O'Bryan, T. L. Lithgow, A. Y. Peleg, J. J. Barr

This study identifies phages targeting Acinetobacter baumannii capsule that induce antimicrobial resensitization by disrupting capsule biosynthesis and enhancing susceptibility to antibiotics and the immune system.

bioRxiv · Feb 25, 2020Microbiology