Author

J. J. Barr

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 7 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 4 Research Focus:host-pathogen & immune response· 3 Organism:bacteria (other)· 2 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Research Focus:benchmarking· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

R. Patwa· 4 shared L. Avellaneda-Franco· 3 shared A. Neild· 2 shared C. Kett· 2 shared D. Subedi· 2 shared M. C. Bichet· 2 shared R. S. Bamert· 2 shared T. Lithgow· 2 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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4 shared papersMicrobiology

R. Patwa

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Temperate gut phages are prevalent, diverse, and predominantly inactive

S. Dahlman, L. Avellaneda-Franco, C. Kett, D. Subedi, R. B. Young, J. A. Gould, E. L. Rutten, E. L. Gilliver, C. J. Turkington, N. Nezam-Abadi, J. A. Grasis, D. Lyras, R. A. Edwards, S. C. Forster, J. J. Barr

The paper characterizes active temperate gut phages from bacterial isolates, finding most are inactive and their induction is complex and context-dependent.

bioRxiv · Aug 17, 2023Microbiology

Rapid assessment of changes in phage bioactivity using dynamic light scattering

T. Dharmaraj, M. J. Kratochvil, J. D. Pourtois, Q. Chen, M. Hajfathalian, A. Hargil, Y.-H. Lin, Z. R. Evans, A. Oromi-Bosch, J. D. Berry, R. McBride, N. L. Haddock, D. R. Holman, J. D. Van Belleghem, T. H. Chang, , P. L. Bollyky

This paper uses Dynamic Light Scattering to assess phage bioactivity changes over time and optimize storage conditions for clinical phage applications.

bioRxiv · Jul 2, 2023Biophysics

Mammalian cells internalize bacteriophages and utilize them as a food source to enhance cellular growth and survival

M. C. Bichet, J. Adderley, L. Avellaneda-Franco, L. J. Gearing, C. Deffrasnes, C. David, G. Pepin, M. P. Gantier, R. C. Lin, R. Patwa, G. W. Moseley, C. Doerig, J. J. Barr

This study shows mammalian cells internalize bacteriophage T4, which enhances cellular growth and survival through AKT-dependent pathways and G1 phase prolongation without triggering inflammatory responses.

bioRxiv · Mar 10, 2023 · PreprintMicrobiology

Diversified repertoire of phage resistance in Klebsiella pneumoniae and bidirectional steering effects impacting antibiotic susceptibility

S. C. Nang, J. Lu, H. H. Yu, H. Wickremasinghe, M. A. K. Azad, M. Han, J. Zhao, G. Rao, P. J. Bergen, T. Velkov, N. Sherry, D. T. McCarthy, S. Aslam, R. T. Schooley, B. P. Howden, , J. Li

The paper investigates phage resistance mechanisms in Klebsiella pneumoniae and shows how these can both increase and decrease antibiotic susceptibility.

bioRxiv · Nov 14, 2022 · PreprintMicrobiology

Bacteriophage adaptation to a mammalian mucosa reveals a trans-domain evolutionary axis

W. H. Chin, C. Kett, O. Cooper, D. Müseler, Y. Zhang, R. S. Bamert, R. Patwa, L. C. Woods, C. Devendran, J. Tiralongo, T. Lithgow, M. J. McDonald, A. Neild, J. J. Barr

This study shows that bacteriophages adapt to the mammalian gut mucosa through mutations and recombination, gaining a fitness advantage by altering their binding to mucin glycans.

bioRxiv · May 11, 2021 · PreprintMicrobiology

The component parts of bacteriophage virions accurately defined by a machine-learning approach built on evolutionary features.

T. Y. Thung, M. E. White, W. Dai, J. J. Wilksch, R. S. Bamert, A. Rocker, C. J. Stubenrauch, D. Williams, C. Huang, R. B. Schittelhelm, J. J. Barr, E. Jameson, S. McGowan, Y. Zhang, J. Wang, , T. Lithgow

This paper develops a machine learning tool called STEP3 to accurately define bacteriophage virion components using evolutionary features, validated with mass spectrometry.

bioRxiv · Feb 28, 2021Microbiology

Bacteriophage uptake by Eukaryotic cell layers represents a major sink for phages during therapy

M. C. Bichet, W. H. Chin, W. Richards, Y.-W. Lin, L. Avellaneda-Franco, C. A. Hernandez, A. Oddo, O. Chernyavskiy, V. Hilsenstein, A. Neild, J. C. Li, N. H. Voelcker, R. Patwa, J. J. Barr

The paper shows that eukaryotic cells internalize phages, with smaller phages being taken up more efficiently, and demonstrates this impacts phage distribution and therapy efficacy.

bioRxiv · Sep 7, 2020Microbiology

Bacteriophages targeting Acinetobacter baumannii capsule induce antimicrobial resensitization

F. L. Gordillo Altamirano, J. H. Forsyth, R. Patwa, X. Kostoulias, M. Trim, D. Subedi, S. Archer, F. C. Morris, C. Oliveira, L. Kielty, D. Korneev, M. K. O'Bryan, T. L. Lithgow, A. Y. Peleg, J. J. Barr

This study identifies phages targeting Acinetobacter baumannii capsule that induce antimicrobial resensitization by disrupting capsule biosynthesis and enhancing susceptibility to antibiotics and the immune system.

bioRxiv · Feb 25, 2020Microbiology