Rational design and implementation of a chemically inducible hetero-trimerization system
H. D. Wu, M. Kikuchi, O. Dagliyan, A. K. Aragaki, H. Nakamura, N. V. Dokholyan, T. Umehara, T. Inoue
This paper designs a chemically inducible trimerization system by splitting FRB and FKBP, enabling precise control of tri-organellar junctions and membrane lipid perturbations in live cells.
bioRxiv · Mar 16, 2020Cell Biology