Cancer BiologybioRxivPreprint
Vulnerability of ARID1A deficient cancer cells to pyrimidine synthesis blockade
Z. Li, S. Mi, O. I. Osagie…·G. S. Huang
This paper identifies ARID1A-deficient cancer cells as vulnerable to pyrimidine synthesis blockade and shows synergy between teriflunomide and AZD6738 in suppressing ARID1A-mutant tumors.
DOI 10.1101/2020.10.12.331975