Engineering protease-resistant peptides to inhibit human parainfluenza viral respiratory infection
V. K. Outlaw, R. W. Cheloha, E. Jurgens, F. T. Bovier, Y. Zhu, D. F. Kreitler, O. K. Harder, S. Niewiesk, M. Porotto, S. H. Gellman, A. Moscona
This paper develops protease-resistant lipopeptides to inhibit HPIV3 infection by modifying the HRC domain, showing improved in vivo stability and antiviral activity in animals.
bioRxiv · Feb 22, 2021Microbiology