The heme biosynthetic enzyme, 5-aminolevulinic acid synthase (ALAS), and GTPases in control of mitochondrial dynamics and ER contact sites, regulate heme mobilization to the nucleus.
O. Martinez-Guzman, M. M. Willoughby, A. Saini, J. V. Dietz, I. Bohovych, A. E. Medlock, O. Khalimonchuk, A. R. Reddi
The paper develops a live-cell assay to study heme trafficking and identifies ALAS and GTPases as regulators of heme mobilization from mitochondria to the nucleus.
bioRxiv · Aug 13, 2019 · PreprintCell Biology