Author

A. E. Medlock

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Research Focus:chromatin & epigenetic regulation· 1 Assay:fluorescence / live-cell microscopy· 1 Assay:proteomics· 1 Organism:yeast· 1

Frequent Co-Authors

A. R. Reddi· 2 shared I. Bohovych· 2 shared J. V. Dietz· 2 shared M. M. Willoughby· 2 shared O. Khalimonchuk· 2 shared A. Saini· 1 shared H. A. Dailey· 1 shared H. G. Addis· 1 shared

Activity by Year

2019-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersBiochemistry

A. R. Reddi

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Author profile →

2 papers

Recent·Most cited

Mitochondrial Contact Site and Cristae Organizing System (MICOS) Machinery Supports Heme Biosynthesis by Enabling Optimal Performance of Ferrochelatase

J. V. Dietz, M. M. Willoughby, R. B. Piel, T. A. Ross, I. Bohovych, H. G. Addis, J. L. Fox, W. N. Lanzilotta, H. A. Dailey, J. A. Wohlschlegel, A. R. Reddi, A. E. Medlock, O. Khalimonchuk

The paper investigates the role of MICOS in regulating ferrochelatase activity and heme biosynthesis in yeast, showing that MICOS disruption leads to toxic tetrapyrrole accumulation.

bioRxiv · Jun 1, 2021Biochemistry

The heme biosynthetic enzyme, 5-aminolevulinic acid synthase (ALAS), and GTPases in control of mitochondrial dynamics and ER contact sites, regulate heme mobilization to the nucleus.

O. Martinez-Guzman, M. M. Willoughby, A. Saini, J. V. Dietz, I. Bohovych, A. E. Medlock, O. Khalimonchuk, A. R. Reddi

The paper develops a live-cell assay to study heme trafficking and identifies ALAS and GTPases as regulators of heme mobilization from mitochondria to the nucleus.

bioRxiv · Aug 13, 2019 · PreprintCell Biology