O. Muehlemann

Universal features of Nsp1-mediated translational shutdown by coronaviruses

This study investigates Nsp1-mediated translational shutdown in three Betacoronaviruses, revealing a conserved mechanism and identifying how Nsp1 allows viral mRNA translation.

Dissecting the import and export pathways of the human RNA helicase UPF1

This study identifies a noncanonical NLS and NES in UPF1, showing that the helicase domain, not RNA binding, is essential for its nuclear shuttling.