Checkpoint activation by Spd1: a competition-based system relying on tandem disordered PCNA binding motifs
J. G. Olsen, A. Prestel, N. Kassem, S. S. Broendum, H. M. Shamim, S. Simonsen, M. Grysbaek, J. Mortensen, L. L. Rytkjaer, G. W. Haxholm, R. Marabini, A. Carr, R. Crehuet, O. Nielsen, B. B. Kragelund
The paper identifies a PIP-box motif in Spd1 that competes with another PCNA binding site to regulate checkpoint activation in yeast.
bioRxiv · May 11, 2023Biophysics