J. G. Olsen

The importance of stereochemistry in the disorder-order continuum of protein-protein interactions

The paper investigates the role of stereochemistry in disordered protein-protein interactions, finding that chirality is inconsequential in fully disordered complexes but essential when folding and binding are coupled.

Checkpoint activation by Spd1: a competition-based system relying on tandem disordered PCNA binding motifs

The paper identifies a PIP-box motif in Spd1 that competes with another PCNA binding site to regulate checkpoint activation in yeast.

Relying on the relationship with known disease-causing variants in homologous proteins to predict pathogenicity of SORL1 variants in Alzheimer's disease

The paper predicts pathogenic SORL1 variants in Alzheimer's disease by analyzing homologous proteins with known disease-causing variants.

Assessment of models for calculating the hydrodynamic radius of intrinsically disordered proteins

The paper evaluates models for calculating the hydrodynamic radius of intrinsically disordered proteins using conformational ensembles validated by small-angle X-ray scattering and finds the Kirkwood-Riseman equation to be the most accurate.

Synergistic stabilization of a double mutant in CI2 from an in-cell library screen

The paper identifies two stabilizing variants of barley chymotrypsin inhibitor 2, showing synergistic effects in a double mutant.

Dynamic NHE1-Calmodulin complexes of varying stoichiometry and structure regulate Ca2+-dependent NHE1 activation

The paper identifies multiple NHE1:CaM complex states with varying stoichiometry and structure, showing how Ca2+ and phosphorylation regulate NHE1 activation.