Author

O. Sen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 3 Organism:human· 2 Assay:imaging· 2 Approach:biophysical modeling· 1 Approach:experimental assay· 1 Approach:microscopy & imaging analysis· 1 Approach:statistical model· 1

Frequent Co-Authors

J. U. Harrison· 3 shared A. D. McAinsh· 2 shared N. J. Burroughs· 2 shared A. McAinsh· 1 shared A. V. Inchingolo· 1 shared C. Castrogiovanni· 1 shared D. Dudka· 1 shared N. Burroughs· 1 shared

Activity by Year

2021-2021 · peak 3/yr

Co-Author Collaboration Network

9 top collaborators · 24 mutual co-author links

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3 shared papersCell Biology

J. U. Harrison

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3 papers

Recent·Most cited

Computational modelling and near-complete kinetochore tracking reveal how chromosome dynamics during cell division are co-ordinated in space and time

J. U. Harrison, O. Sen, A. McAinsh, N. Burroughs

The paper tracks kinetochore dynamics during mitosis and develops a biophysical model to show that metaphase oscillations are robust to mechanical variation, with local coordination across the spindle.

bioRxiv · Dec 16, 2021 · PreprintCell Biology

Microtubule-based mitotic spindles contain a micron-sized mixed-nucleotide zone

C. Castrogiovanni, A. V. Inchingolo, J. U. Harrison, D. Dudka, O. Sen, N. J. Burroughs, A. D. McAinsh, P. Meraldi

The paper reveals a mixed-nucleotide zone in mitotic spindle microtubules, between the GTP-cap and GDP-tubulin lattice, identified through HURP localization and computational simulation.

bioRxiv · Jul 23, 2021 · PreprintCell Biology

Kinetochore life histories reveal the origins of chromosome mis-segregation and correction mechanisms

O. Sen, J. U. Harrison, N. J. Burroughs, A. D. McAinsh

The paper uses microscopy and computational analysis to study kinetochore dynamics, revealing that chromosome mis-segregation is common and corrected early in anaphase through Aurora B-dependent mechanisms.

bioRxiv · Mar 30, 2021 · PreprintCell Biology