N. J. Burroughs

Microtubule-based mitotic spindles contain a micron-sized mixed-nucleotide zone

The paper reveals a mixed-nucleotide zone in mitotic spindle microtubules, between the GTP-cap and GDP-tubulin lattice, identified through HURP localization and computational simulation.

Kinetochore life histories reveal the origins of chromosome mis-segregation and correction mechanisms

The paper uses microscopy and computational analysis to study kinetochore dynamics, revealing that chromosome mis-segregation is common and corrected early in anaphase through Aurora B-dependent mechanisms.

Ensemble-level organization of human kinetochores and evidence for distinct tension and attachment sensors

The paper uses fluorescence localisation to study the organization of kinetochore proteins and identifies two mechanical sensors involved in monitoring attachment and tension.

The dynamics of centromere motion through the metaphase-to-anaphase transition reveal a centromere separation order

The paper uses high-speed imaging and Bayesian modeling to show centromeres separate asynchronously during anaphase, with timing linked to metaphase distance and affected by condensin complexes.

Structural-mechanical remodelling of GDP-microtubules by kinesin

This study shows that kinesin-1 motor domains inhibit GDP-microtubule shrinkage and expand lattice spacing, revealing a new mechanochemical mechanism linking kinesin and tubulin.