A. D. McAinsh

Age-dependent loss of cohesion protection in human oocytes

This study shows that loss of Sgo2 at the pericentromere bridge in aging human oocytes weakens sister chromatid cohesion, contributing to aneuploidy.

Microtubule-based mitotic spindles contain a micron-sized mixed-nucleotide zone

The paper reveals a mixed-nucleotide zone in mitotic spindle microtubules, between the GTP-cap and GDP-tubulin lattice, identified through HURP localization and computational simulation.

Kinetochore life histories reveal the origins of chromosome mis-segregation and correction mechanisms

The paper uses microscopy and computational analysis to study kinetochore dynamics, revealing that chromosome mis-segregation is common and corrected early in anaphase through Aurora B-dependent mechanisms.

The First Mitotic Division of the Human Embryo is Highly Error-prone

The paper films chromosome segregation during the first two mitotic divisions in human embryos, showing the first division is highly error-prone and variable.

Ensemble-level organization of human kinetochores and evidence for distinct tension and attachment sensors

The paper uses fluorescence localisation to study the organization of kinetochore proteins and identifies two mechanical sensors involved in monitoring attachment and tension.

The dynamics of centromere motion through the metaphase-to-anaphase transition reveal a centromere separation order

The paper uses high-speed imaging and Bayesian modeling to show centromeres separate asynchronously during anaphase, with timing linked to metaphase distance and affected by condensin complexes.

Single molecule mechanics reveal Kif15 as an active molecular ratchet with acute strain sensitivity

This study investigates the single molecule mechanics of Kif15, revealing its strain sensitivity and directional load-dependent behavior.