Author

Oana Kubinyecz

Babraham Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Developmental Biology· 3

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Assay:scRNA-seq· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:statistical model· 1

Frequent Co-Authors

Fátima SantosiD· 3 shared Mélanie A. Eckersley-MasliniD· 3 shared Wolf ReikiD· 3 shared Celia Alda-CatalinasiD· 2 shared Deborah Drage· 2 shared Christel KruegeriD· 1 shared Danila BredikhiniD· 1 shared Hanneke OkkenhaugiD· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersDevelopmental Biology

Fátima SantosORCID

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3 papers

Recent·Most cited

Maternal SMARCA5 is required for major ZGA in mouse embryos

Oana Kubinyecz, Deborah Drage, Fátima Santos, Christel Krueger, Hanneke Okkenhaug, Celia Alda-Catalinas, Mélanie A. Eckersley-Maslin, Jasmin Taubenschmid, Wolf Reik

This study shows that maternal SMARCA5 is essential for major ZGA in mouse embryos by regulating promoter and distal regulatory region accessibility and nucleosome positioning.

bioRxiv · Dec 5, 2023 · PreprintDevelopmental Biology

Maternal Dppa2 and Dppa4 are dispensable for zygotic genome activation but important for offspring survival

Oana Kubinyecz, Fátima Santos, Deborah Drage, Wolf Reik, Mélanie A. Eckersley-Maslin

This study shows Dppa2/4 are not required for zygotic genome activation but are important for offspring survival, as maternal depletion leads to reduced litter size and increased preweaning lethality.

Development · Dec 15, 2021Peer-reviewedDevelopmental Biology

A single-cell transcriptomics CRISPR-activation screen identifies new epigenetic regulators of zygotic genome activation

Celia Alda-Catalinas, Danila Bredikhin, Irene Hernando-Herraez, Fátima Santos, Oana Kubinyecz, Mélanie A. Eckersley-Maslin, Oliver Stegle, Wolf Reik

The paper uses CRISPR-activation and single-cell RNA-seq to identify 44 epigenetic regulators that induce a zygotic genome activation-like state in mouse embryonic stem cells.

Cell Systems · Jul 1, 2020Peer-reviewedDevelopmental Biology