Irene Hernando-Herraez

This paper introduces scDynaBar, a method using CRISPR barcoding to track temporal cellular events at single-cell resolution, showing the transient nature of the 2C-like state in mESCs.

This paper introduces a method to rejuvenate human fibroblasts by transient reprogramming to the maturation phase of iPSCs, followed by recovery of fibroblast identity, resulting in significant rejuvenation of transcriptome, epigenome, and functional markers.

This study identifies molecular differences between extraocular and limb muscle stem cells, showing that EOM MuSCs reprogram their transcriptome and epigenome after transplantation, with some genes resisting engraftment.

The paper uses CRISPR-activation and single-cell RNA-seq to identify 44 epigenetic regulators that induce a zygotic genome activation-like state in mouse embryonic stem cells.

The paper compares gene expression and DNA methylation across tissues and species in primates, finding that only 7-11% of inter-species expression differences are explained by methylation, with higher explanation in tissue-specific genes.

This study shows that ageing increases transcriptional heterogeneity and DNA methylation drift in muscle stem cells, disrupting transcriptional networks and stem cell function.

This study compares single-cell transcriptomes of human, marmoset, and mouse embryos to identify conserved and divergent features of preimplantation development.

This study identifies human-specific DNA methylation patterns and their relationship with genetic variation in humans and great apes.

The paper generates a panel of chimpanzee iPSCs and compares their regulatory variation with somatic cells and human iPSCs, finding reduced species-specific differences in iPSCs.